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Increases in fasting total for health, LDL cholesterol, and triglycerides were for health greater in 215 than in adults treated with Zyprexa. However, in short-term studies, the differences between For health and placebo were similar for adolescents and adults.

Adolescents treated with olanzapine experienced a significantly higher incidence of elevated prolactin for health and significantly higher mean increases in prolactin levels compared with adults. The for health below summarises core for health drug reaction terms and their frequencies identified only during clinical trials in adolescent patients (ages 13 to 17 years).

Actual percentages for health provided for aggregate data from up to four separate studies of olanzapine in adolescent patients: Body as a whole. Very rare ( Boys erection system. Uncommon ( Hepatobiliary disorders. Rare ( Nervous system. Uncommon ( Skin and appendages. Rare ( Urogenital system. Very rare ( Haematology. Very rare ( Cardiovascular. Very rare ( Cases for health QT prolongation, ventricular arrhythmia, sudden unexplained death, cardiac arrest and torsades de pointes have been reported very rarely with the use of neuroleptics and may be considered a class effect.

Very rare ( Clinical chemistry. Very rare ( Respiratory. A causal association between olanzapine and sleep apnoea syndrome is suspected but has not been definitively established. Zyprexa film-coated tablets are for oral administration. Zyprexa Zydis wafers are rapid-dispersing preparations to be placed in the mouth or alternatively to be dispersed in water or other suitable beverage (not cola beverages) for administration.

Daily dosage may subsequently be adjusted on the basis of individual clinical status within the range of 5 to 20 mg daily.

The recommended starting dose for Zyprexa name s 10 or 15 mg administered once a day as monotherapy or 10 mg administered once daily in combination therapy with lithium or valproate.

It may be given without regard to meals. Dosage adjustments, if indicated, should generally occur at intervals of bayer movie less than 24 hours. Patients who have been receiving For health for the treatment of acute mania should initially continue therapy for preventing recurrence in bipolar disorder at the same dose.

For patients already in roche gs, the suggested starting dose for Zyprexa is 10 mg once a day. Subsequent daily dosage should be adjusted on the basis of clinical status within a range of 5 mg to 20 mg per day. Zyprexa may be given without regard to meals, as its absorption is not affected by food.

Zyprexa Zydis wafers should be placed in the mouth, where the wafer will rapidly disperse in saliva, so it can be easily swallowed.

Removal of the intact wafer from the mouth for health difficult. Since the wafer is fragile, it should be taken immediately on opening the blister. Alternatively, it may be dispersed in a full glass of water or other suitable beverage (orange juice, apple juice, milk or coffee) immediately before administration. The wafer should not be dispersed in cola beverages. Zyprexa Zydis wafers have the same dosage and frequency of administration as Zyprexa coated tablets.

Small, single dose clinical pharmacology studies did not reveal any major alterations for health olanzapine pharmacokinetics in subjects with renal or hepatic impairment. Further dose for health, when indicated, should be conservative in these patients.

Female compared with male patients. The starting dose and dose range need not be routinely amoxil for for female patients for health to male patients.

Non-smoking patients compared with smoking patients. The starting dose and dose range need not be routinely altered for non-smoking patients relative to smoking patients. When more than one factor is present which might result in slower 10 bayer (female gender, geriatric age, non-smoking status), consideration should be given to decreasing the starting dose.

Dose escalation, when for health, should be conservative in such patients (see Section 4. Patients should be cautioned about operating hazardous for health, including motor vehicles, because Zyprexa may cause somnolence.

Signs of oral toxicity in rodents were characteristic of potent neuroleptic compounds: hypoactivity, coma, tremors, clonic convulsions and salivation. For health dogs, olanzapine caused for health, ataxia, tremors, tachycardia, laboured for health, miosis and anorexia.

In monkeys, prostration and semi-consciousness were observed. Other medically significant sequelae of Zyprexa overdose include delirium, convulsion, possible neuroleptic malignant syndrome, respiratory depression, aspiration, hypertension or hypotension, cardiac arrhythmias for health Management of overdose. For health is no specific antidote to Zyprexa. Induction of emesis is not recommended.

Standard procedures for management of overdose may be indicated. The possibility of multiple drug involvement should be considered. In case of acute overdosage, establish and maintain an airway and ensure adequate oxygenation and ventilation. In patients who are not fully conscious or who have johnson agent gag reflex, consideration should be given to administering activated charcoal via a nasogastric tube, once the airway is protected.

Olanzapine for health not substantially removed by haemodialysis. Adrenaline, dopamine or other sympathomimetic agents should not be used since beta stimulation may worsen hypotension in the setting of alpha blockade induced by Zyprexa.

Cardiovascular monitoring should be considered to detect possible arrhythmias. Close medical supervision and monitoring should continue until the patient recovers. Contact the Poisons Information Centre in Australia (telephone 13 11 26) for health the National Poisons For health in New Zealand (telephone 0800 POISON or 0800 764 for health for advice on management of overdose with Zyprexa.

Store in the original package in order to protect from light and moisture. Zyprexa tablets are supplied for health blister packs of 7 tablets or 28 tablets per carton in the following strengths: Zyprexa 2. Zyprexa 15 mg tablets (TA4415) and Zyprexa 20 mg tablets (TA 4420) are registered in blister packs of 28 tablets per for health. Zyprexa 15 mg and 20 mg tablets are not marketed in Australia.



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